I wish my Dr told me that weight gain was a side effect. Gained about 10 pounds in about 3-4 months. I have been off the medication for 3 months now. Hi! I am 60 and have been thru hair loss 4 times due to various medications, namely Topomax, Trazadone, Ambien, and Xanax. My hair came back beautifully after getting off the Trazadone, but to sleep, I started on Ambien (I have chronic insomnia). Going through the same here starting at age 48. Have jitters (general shakiness in my chest, perhaps anxiety, perhaps palps, who knows) which is the worst feeling. Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone. Spironolactone is a synthetic steroidal drug that causes loss of libido, depression, and fatigue. It masks symptoms but doesn't solve any hormonal problem. Metabolic Changes With Age. You may be wondering what happens with insulin and cardiovascular parameters as women with PCOS age. It has been established that women with PCOS have higher levels of insulin than women without PCOS, independent of weight. I got an email from Tracy regarding a post she found on another website about a woman writing about her success with Spironolactone, so I’m posting it here for all of you. I was hoping someone could help me with what to do about the weight gain. I have always eaten healthy and exercised but it doesn't help. Last month I hardly ate much (skipped dinner most nights) and my clothes still feel tighter. Weight loss with PCOS can feel virtually impossible! There are a number of factors that make losing weight with PCOS really difficult. Here is why. I thought I was going crazy. I'm eating less and still gained 55 pounds. I thought it was the blocks. But now I see. What's funny is that even though the studies say 2/3 % reported weight gain.